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Browsing *Ingenierías y Ciencias de la Computación (Proyecto VLIR) by Issue Date

Browsing *Ingenierías y Ciencias de la Computación (Proyecto VLIR) by Issue Date

Now showing items 1-20 of 4324

Exploiting Hierarchical Domain Structure to Compute Similarity

Ganesan Prasanna; Garcia-Molina Hector; Widom Jennifer (1904)

The notion of similarity between objects finds use in many contexts, for example, in search engines, collaborative filtering, and clustering. Objects being compared often are modeled as sets, with their similarity traditionally ...
Early User—System Interaction for Database Selection in Massive Domain-Specific Online Environments Early User—System Interaction for Database Selection

Thomson Jack G Conrad; Claussen Joanne R S (1904)

The continued growth of very large data environments such as Westlaw and Dialog, in addition to the World Wide Web, increases the importance of effective and efficient database selection and searching. Current research ...
Approximate Spatio-Temporal Retrieval

Papadias Dimitris; Kong Hong; Cwi Nikos Mamoulis; Delis Vasilis (1910)

This paper proposes a framework for the handling of spatio-temporal queries with inexact matches, using the concept of relation similarity. We initially describe a binary string encoding for 1D relations that permits the ...
A Statechart-Based Model for Hypermedia Applications

Ferreira Maria Cristina; Oliveira De (1910)

This paper presents a formal definition for HMBS (Hypermedia Model Based on Statecharts). HMBS uses the structure and execution semantics of statecharts to specify both the structural organization and the browsing semantics ...
An Active-Site Mutation in the Human Immunodeficiency Virus Type 1 Proteinase (PR) Causes Reduced PR Activity and Loss of PR-Mediated Cytotoxicity without Apparent Effect on Virus Maturation and Infectivity

Konvalinka Jan; Litterst † Mark A; Welker Reinhold; Kottler ‡ Hubert; Rippmann Friedrich; Heuser Anke-Mareil; Kra¨usslichkra¨kra¨usslich Hans-Georg (1995)

Infectious retrovirus particles are derived from structural polyproteins which are cleaved by the viral proteinase (PR) during virion morphogenesis. Besides cleaving viral polyproteins, which is essential for infectivity, ...
An Active-Site Mutation in the Human Immunodeficiency Virus Type 1 Proteinase (PR) Causes Reduced PR Activity and Loss of PR-Mediated Cytotoxicity without Apparent Effect on Virus Maturation and Infectivity

Konvalinka Jan; Litterst † Mark A; Welker Reinhold; Kottler ‡ Hubert; Rippmann Friedrich; Heuser Anke-Mareil; Kra¨usslichkra¨kra¨usslich Hans-Georg (1995)

Infectious retrovirus particles are derived from structural polyproteins which are cleaved by the viral proteinase (PR) during virion morphogenesis. Besides cleaving viral polyproteins, which is essential for infectivity, ...
Cross-Resistance Analysis of Human Immunodeficiency Virus Type 1 Variants Individually Selected for Resistance to Five Different Protease Inhibitors

Tisdale Margaret; Myers Richard E; Maschera Barbara; Parry Nigel R; Oliver Nicholas M; Blair Edward D (1995)

Human immunodeficiency virus type 1 (HIV-1) protease inhibitor-resistant variants, isolated on passage of HIV-1 HXB2 in MT-4 cells with five different protease inhibitors, have been examined for cross-resistance to five ...
In Vitro Selection and Characterization of Human Immunodeficiency Virus Type 1 (HIV-1) Isolates with Reduced Sensitivity to Hydroxyethylamino Sulfonamide Inhibitors of HIV-1 Aspartyl Protease

Partaledis Judith A; Yamaguchi Koushi; Tisdale Margaret; Blair Edward E; Falcione Cristina; Maschera Barbara; Myers Richard E; Pazhanisamy S; Futer Olga; Cullinan Aine B; Stuver Cameron M; Byrn Randal A; Livingston David J (1995)

Human immunodeficiency virus type 1 (HIV-1) variants with reduced sensitivity to the hydroxyethylamino sulfonamide protease inhibitors VB-11,328 and VX-478 have been selected in vitro by two independent serial passage ...
Characterization of a Human Immunodeficiency Virus Type 1 Variant with Reduced Sensitivity to an Aminodiol Protease Inhibitor

Patick Amy K; Rose Ronald; Greytok Jill; Bechtold Clifford M; Hermsmeier Mark A; Chen Peter T; Barrish Joel C; Zahler Robert; Colonno Richard J; Lin And Pin-Fang (1995)

Development of viral resistance to the aminodiol human immunodeficiency virus (HIV) protease inhibitor BMS 186,318 was studied by serial passage of HIV type 1 RF in MT-2 cells in the presence of increasing concentrations ...
In Vitro Selection and Characterization of Human Immunodeficiency Virus Type 1 (HIV-1) Isolates with Reduced Sensitivity to Hydroxyethylamino Sulfonamide Inhibitors of HIV-1 Aspartyl Protease

Partaledis Judith A; Yamaguchi Koushi; Tisdale Margaret; Blair Edward E; Falcione Cristina; Maschera Barbara; Myers Richard E; Pazhanisamy S; Futer Olga; Cullinan Aine B; Stuver Cameron M; Byrn Randal A; Livingston David J (1995)

Human immunodeficiency virus type 1 (HIV-1) variants with reduced sensitivity to the hydroxyethylamino sulfonamide protease inhibitors VB-11,328 and VX-478 have been selected in vitro by two independent serial passage ...
Calulus of fuzzy restrictions fuzzy sets and their applications

Zadeh L A; Zadeh Lotfi A; Fu King-Sun; Tanaka Kokichi; Shimura Masamichi; Zadeh Lotfi A; Fu King-Sun; Tanaka Kokichi; Shimura Masamichi; Zadeh L A (1995)

A fuzzy restriction may be visualized as an elastic constraint on the values that may be assigned to a variable. In terms of such restrictions, the meaning of a proposition of the form "x is P," where x is the name of an ...
Calculus of fuzzy restrictions fuzzy sets and their applications

Zadeh L A; Zadeh Lotfi A; Fu King-Sun; Tanaka Kokichi; Shimura Masamichi; Zadeh Lotfi A; Fu King-Sun; Tanaka Kokichi; Shimura Masamichi; Zadeh L A (1995)

A fuzzy restriction may be visualized as an elastic constraint on the values that may be assigned to a variable. In terms of such restrictions, the meaning of a proposition of the form "x is P," where x is the name of an ...
Logitlinear models for the prediction of splice sites in plant pre-mRNA sequences

Kleffe Jürgen; Hermann Klaus; Vahrson Wolfgang; Wittig Burkhardt; Brendel Volker (1996)

Pre-mRNA splicing in plants, while generally similar to the processes in vertebrates and yeast, is thought to involve plant specific cis-acting elements. Both mono-cot and dicot introns are typically strongly enriched in ...
Very Fast Identification of RNA Motifs in Genomic DNA. Application to tRNA Search in the Yeast Genome

El-Mabrouk Nadia; Lisacek Fré Dé Rique (1996)

A common strategy characterises the various methods independently 1 Institut Gaspard Monge defined to identify almost unambiguously different types of RNA Université de Marne-la-Vallée, 2 rue de la molecules in DNA fragments. ...
Second Locus Involved in Human Immunodeficiency Virus Type 1 Resistance to Protease Inhibitors

Doyon Louise; Croteau Gilbert; Thibeault Diane; Poulin Francis; Pilote Louise; Lamarre Daniel (1996)

Protease inhibitors are potent antiviral agents against human immunodeficiency virus type 1. As with reverse transcriptase inhibitors, however, resistance to protease inhibitors can develop and is attributed to the appearance ...
In Vivo Sequence Diversity of the Protease of Human Immunodeficiency Virus Type 1: Presence of Protease Inhibitor- Resistant Variants in Untreated Subjects

Lech Walter J; Wang Greg; Yang Yan Li; Chee Ying; Dorman Karin; Mccrae Derek; Lazzeroni Laura C; Erickson John W; Sinsheimer Janet S; Kaplan Andrew H (1996)

We have evaluated the sequence diversity of the protease of human immunodeficiency virus type 1 in vivo. Our analysis of 246 protease coding domain sequences obtained from 12 subjects indicates that amino acid substitutions ...
Genetic Correlates of In Vivo Viral Resistance to Indinavir, a Human Immunodeficiency Virus Type 1 Protease Inhibitor

Condra Jon H; Holder Daniel J; Schleif William A; Blahy Olga M; Danovich Robert M; Gabryelski Lori J; Graham Donald J; Laird Donna; Quintero Julio C; Rhodes Audrey; Robbins Helen L; Roth Elizabeth; Shivaprakash Malathi; Yang Tao; Chodakewitz Jeffrey A; Deutsch Paul J; Leavitt Randi Y; Massari Ferdinand E; Mellors John W; Squires Kathleen E; Steigbigel Roy T; Teppler Hedy; Emini Emilio A (1996)

Indinavir (IDV) (also called CRIXIVAN, MK-639, or L-735,524) is a potent and selective inhibitor of the human immunodeficiency virus type 1 (HIV-1) protease. During early clinical trials, in which patients initiated therapy ...
Emergence of Protease Inhibitor Resistance Mutations in Human Immunodeficiency Virus Type 1 Isolates from Patients and Rapid Screening Procedure for Their Detection

Vasudevachari M B; Zhang Y.-M; Imamichi H; Imamichi T; Falloon J; Salzman N P (1996)

Patient human immunodeficiency virus type 1 (HIV-1) isolates that are resistant to protease inhibitors may contain amino acid substitutions L10I/V, M46L/I, G48V, L63P, V82A/F/T, I84V, and L90M in the protease gene. ...
Impaired Fitness of Human Immunodeficiency Virus Type 1 Variants with High-Level Resistance to Protease Inhibitors

Croteau Gilbert; Doyon Louise; Thibeault Diane; Mckercher Ginette; Pilote Louise; Lamarre Daniel (1996)

One hope to maintain the benefits of antiviral therapy against the human immunodeficiency virus type 1 (HIV-1), despite the development of resistance, is the possibility that resistant variants will show decreased viral ...
Antiviral and Resistance Studies of AG1343, an Orally Bioavailable Inhibitor of Human Immunodeficiency Virus Protease AG1343 ([3S-(3R * , 4aR * , 8aR * , 2S * , 3S * )]-2-[2 hydroxy-3-phenylthiomethyl-4-aza-5-oxo-5-(2-methyl- 3-hydroxy-phenyl

Patick A K; Mo H; Markowitz M; Appelt K; Wu B; Musick L; Kalish V; Kaldor S; Reich S; Ho D; Webber And S (1996)

pentyl]-decahydroiso-quinoline-3-N-t-butylcarboxamide methanesulfonic acid) is a selective , nonpeptidic inhibitor of human immunodeficiency virus (HIV) protease (K i 2 nM) that was discovered by protein structure-based ...

Browsing *Ingenierías y Ciencias de la Computación (Proyecto VLIR) by Issue Date

Browsing *Ingenierías y Ciencias de la Computación (Proyecto VLIR) by Issue Date

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